SEHSC - Silicones Evironmental, Health, and Safety Council of North America
Siloxane Research Program

SRP Journal Publications

Published | Submitted for Publication

  1. Varaprath, S, Salyers, K.l., Plotzke, K.P., and Nanavati, S., Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrixes. Anal. Biochem., 256 (l), 14-22, 1998.
  2. Burns, L.A., Mast, R.W., Meeks, R.G., Mann, P.C., and Thevenaz, P., Inhalation Toxicology of Decamethylcyclopentasiloxane (D5) Following a 3-Month Nose-Only Exposure in Fischer 344 Rats. Toxicological Sciences 43:230-240, 1998.
  3. Burns, L.A., Mast, R.W., Klykken, P.C., McCay, J.A., White, K.L., Mann, P.W., and Naas, D.J., Toxicology and humoral immunity assessment of decamethylcyclopentasiloxane (D5) following a 28-day whole body inhalation exposure in Fischer 344 rats. Toxicological Sciences 43:28-38, 1998.
  4. Looney,R.J., Frampton, M.W., Byam, J., Kenaga,C., Speers, D.M., Cox, C., Mast, R.W., Klykken, P.C., Morrow, P.E., and Utell, M.J., Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects. Toxicological Sciences, 44, 214-220, 1998.
  5. Utell, M.J., Gelein, R., Yu, C.P., Kenaga, C., Torres, A. Chalupa, D., Gibb, F.R., Speer,, D.M., Mast, R.W. and Morrow, P.E., Quantitative exposure of humans to octamethylcyclotetrasiloxane (D4) vapor. Toxicological Sciences, 44, 206-213, 1998.
  6. McKim, J.M., Jr., Wilga, P.C., Kolesar, G.B., Choudhuri, S., Madan, A., Dochterman, L.W., Breen,J.G., Parkinson, A., Mast, R.W., and Meeks, R.G., Evaluation of Octamethylcyclotetrasiloxane (D4) as an Inducer of Rat Hepatic Microsomal Cytochrome P450, UDP-glucuronyl transferase, and Epoxide Hydrolase: A 28-Day Inhalation Study. Toxicological Sciences Vol. 41, No. 1, 29-41 (1998).
  7. Klykken, P.C., Galbraith, T. W., Kolesar, G. B., Jean, P. A., Woolhiser, M. R., Elwell, M. R., Burns-Naas, L. A., Mast, R. W., McCay, J. A., White, K. L., and Jr., Munson, A. E., Toxicology and Humoral Immunity Assessment of Octamethylcyclotetrasiloxane (D4) Following a 28 day Whole Body Vapor Inhalation Exposure in Fischer 344 Rats. Drug and Chemical Toxicology, (1998).
  8. Varaprath, S., Synthesis of 14C-Labeled cyclic and linear siloxanes. J. Organomet. Chem., 572, 37-47, (1999).
  9. McKim, J.M. Jr., Choudhuri, S., Wilga, P.C., Madan, A., Burns-Naas, L.A., Gallavan, R.H., Mast, R.W., Naas, D.J., Parkinson, A., and Meeks, R.G., Evaluation of decamethylcyclopentasiloxane (D5) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study. Toxicological Sciences, 50, 10-19 (1999).
  10. Varaprath, S., Salyers, K.L., Plotzke, K.P., and Nanavati, S., Identification of Metabolites of Octamethylcyclotetrasiloxane (D4) in Rat Urine. Drug Metabolism and Disposition, 27 (11) (1999).
  11. Plotzke, K.P., Crofoot, S.D., Ferdinandi, E.S., Beattie, J.G., Reitz, R.H., McNett, D.A., and Meeks, R.G., Disposition of Radioactivity in Fischer 344 Rats Following Single and Multiple Inhalation Exposure to 14C-Octamethylcyclotetrasiloxane (14C-D4). Drug Metabolism and Disposition, 28 (2) (2000).
  12. Varaprath, S. and Lin, C., Efficient Solid Phase Extraction Procedures for Siloxanes from Aqueous and Biological Matrices. J. Liq. Chromatography. Relat. Technol., 23 (10), 1539-1553, (2000).
  13. Varaprath, S.,. Seaton, M., McNett, D., Cao, L., and Plotzke, K.P., Quantitative Determination of Octamethylcyclotetrasiloxane (D4) in Extracts of Biological Matrices by Gas Chromatography-Mass Spectrometry. J.Environ. Anal. Chem. 77 (3) 203-219 (2000).
  14. Vergnes J.S., Jung, R., Thakur, A.K., Barfknecht, T.R., and Reynolds, V.L., Genetic Toxicity Evaluation of Octamethylcyclotetrasiloxane. Environmental and Molecular Mutagenesis 36:13-21 (2000).
  15. Andersen M.E., Sarangapani, R., Reitz, R.H., Gallavan, R. H., Dobrev, I.D., and Plotzke, K.P., Physiological Modeling Reveals Novel Pharmacokinetic Behavior For Inhaled Octamethylcyclotetrasiloxane in Rats. Toxicological Sciences, 60, 214-231 (2001).
  16. McKim, J.M. Jr., Kolesar, G. B., Jean, P.A., Meeker, L.S., Wilga, P.C., Schoonhoven, R., Swenberg, J. A.. Goodman, J.I.; Gallavan, R.H.; and Meeks, R.G., Repeated Inhalation Exposure to Octamethylcyclotetrasiloxane (D4) Produces Hepatomegaly, Transient Hepatic Hyperplasia, and Sustained Hypertrophy in Female Fischer 344 Rats in a Manner Similar to Phenobarbital. Toxicology and Applied Pharmacology, 172, 83-92, (2001).
  17. McKim, J.M. Jr., Wilga, P.C., Breslin, W.J., Plotzke, K.P., Gallavan, R.H., and Meeks, R.G., Potential Estrogenic and Antiestrogenic Activity of the Cyclic Siloxane Octamethylcyclotetrasiloxane (D4) and the Linear Siloxane Hexamethyldisiloxane (HMDS) In Immature Rats Using the Uterotrophic Assay. Toxicological Sciences 63.
  18. Burns-Naas, Meeks, R.G., Kolesar, G.B., Mast, R.W., Elwell, M.R., Hardisty, J.R., and Thevenaz, P., Inhalation Toxicology of Octamethylcyclotetrasiloxane (D4) Following a 3-Month Nose-Only Inhalation Exposure in Fischer 344 Rats. Int J Toxicol., 21(1):39-53. (2002).
  19. Zareba, G., Percutaneous Absorption Studies of Octamethylcyclotetrasiloxane (D4) Using The Human Skin/Nude Mouse Model. Skin Pharmacol Appl Skin Physiol., 15(3):184-94. (2002).
  20. Cassidy, S.L., Dotti, A., Kolesar, G. B., Dochterman, L. W., Meeks, R. G., Chevalier, H. J., Hexamethyldisiloxane: A 13-Week Subchronic Whole-Body Vapor Inhalation Toxicity Study in F344 Rats. Int J Toxicol., 20(6):391-9. (2001).

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